来自红曲霉菌黄色突变体的氮杂环庚三烯酮色素。
Azaphilone pigments from a yellow mutant of the fungus Monascus kaoliang.
作者信息
Jongrungruangchok Suchada, Kittakoop Prasat, Yongsmith Busaba, Bavovada Rapepol, Tanasupawat Somboon, Lartpornmatulee Nattapat, Thebtaranonth Yodhathai
机构信息
Department of Microbiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
出版信息
Phytochemistry. 2004 Sep;65(18):2569-75. doi: 10.1016/j.phytochem.2004.08.032.
Azaphilone pigments, monascusones A (1) and B (2), together with two known azaphilones, monascin (3) and FK17-P2b2 (4), were isolated from the CH2Cl2 extract of a yellow mutant of the fungus M. kaoliang grown on rice. Structures of the isolated compounds were elucidated by analyses of spectroscopic data. Monascusone A (1), the major metabolite of M. kaoliang, showed no antimalarial (against Plasmodium falciparum), antitubercular (against Mycobacterium tuberculosis H37Ra), and antifungal (toward Candida albicans) activities. Compound 1 exhibited no cytotoxicity against BC (breast cancer) and KB (human epidermoid carcinoma of cavity) cell lines.
从在大米上生长的红曲霉菌黄色突变体的二氯甲烷提取物中分离出了氮杂环庚三烯酮色素红曲菌素A（1）和B（2），以及两种已知的氮杂环庚三烯酮红曲红素（3）和FK17 - P2b2（4）。通过光谱数据分析阐明了分离出的化合物的结构。红曲菌素A（1）是红曲霉的主要代谢产物，对恶性疟原虫无抗疟活性，对结核分枝杆菌H37Ra无抗结核活性，对白色念珠菌无抗真菌活性。化合物1对乳腺癌（BC）细胞系和人口腔表皮样癌（KB）细胞系无细胞毒性。
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