Saruki N, Johnokoshi H, Tozawa R, Fujita T
Department of Anesthesiology, Gumma Cancer Center Hospital, Ota.
Masui. 1992 Jan;41(1):100-5.
An analgesic is often administered upon the occurrence of pain following surgery. Buprenorphine hydrochloride suppository (0.2 mg) was given immediately postoperatively to patients who had undergone surgery under general anesthesia. Post-operative pain has been observed after 782 +/- 41 minutes (n = 148, mean +/- SE) in the patients with suppository and 127 +/- 18 minutes (n = 57) in the control group (P less than 0.01). Analgesics were given to 68% of the control group within 2 hours, while it was given to 14% of the study group. Further 57% of the latter did not complain of any pain after 20 hours. The pharmacokinetics of buprenorphine was studied in 7 patients. Intrarectal administration of 0.2 mg buprenorphine suppository just after surgery had a sufficient analgesic action and did not induce any adverse reactions of any clinical importance.
术后疼痛发生时通常会给予镇痛药。对接受全身麻醉手术的患者，术后立即给予盐酸丁丙诺啡栓剂（0.2毫克）。栓剂组患者术后782±41分钟（n = 148，均值±标准误）出现疼痛，而对照组为127±18分钟（n = 57）（P＜0.01）。对照组68%的患者在2小时内使用了镇痛药，而研究组这一比例为14%。此外，研究组57%的患者在20小时后未主诉任何疼痛。对7名患者进行了丁丙诺啡的药代动力学研究。术后立即经直肠给予0.2毫克丁丙诺啡栓剂具有足够的镇痛作用，且未引发任何具有临床意义的不良反应。
