Ionescu M, Dumitraşcu T, Stroescu C, Bărbuţă S, Tomulescu V, Popescu I
Centrul de Chirurgie Generală şi Transplant Hepatic, Institutul Clinic Fundeni.
Chirurgia (Bucur). 2004 May-Jun;99(3):125-35.
Ulcerative colitis (UC) is an inflammatory bowel disease that may be cured by surgery being indicated for emergency situations resulting from complications of fulminant disease and for elective indications. We analyzed the last 24 years experience regarding 50 patients surgically treated for ulcerative colitis in the Center of General Surgery and Liver Transplantation of Fundeni Clinical Institute. The indications for surgery were: failure of medical treatment in 22 patients, acute disease with complications in 20, chronic complications in 8 cases. We used the following surgical procedures: total proctocolectomy in all 2 cases with associated rectal cancer, total colectomy with ileo-rectal anastomosis (one staged or two staged procedures) in 31, and restorative proctocolectomy in 17 cases (in all cases as a 2 or 3 staged procedure). In acute disease with complications we have performed total colectomy with terminal ileostomy, closure of the rectal stump, or exteriorization of the sigmoid stump in a mucous fistula. The gravity of acute complications does not justify the use of palliative procedures such as ileostomy, colostomy or Hartmann procedure because the mortality rate of these operations is higher than the postoperative mortality rate of total colectomy performed in emergency. Even in the elective surgery, when the patients are in a poor condition, nutritionally depleted, taking large doses of steroids or immunosuppressive drugs, we prefer the staged procedure. Total proctocolectomy is performed only in the cases of ulcerative colitis associated with rectal cancer, severe perianal disease, sphincter incontinence. Total colectomy with ileo-rectal anastomosis is indicated when the rectal stump has minimal inflammatory lesions. Restorative proctocolectomy is the surgery of choice for UC, the functional results being comparable with those of total colectomy with ileo-rectal anastomosis, but having the advantage of curing the disease. The global mortality rate was 12% (6 patients).
溃疡性结肠炎(UC)是一种炎症性肠病,在暴发性疾病并发症导致的紧急情况以及择期手术指征下,可通过手术治愈。我们分析了Fundeni临床研究所普通外科和肝移植中心过去24年中50例接受溃疡性结肠炎手术治疗患者的经验。手术指征为:22例药物治疗失败,20例急性疾病伴并发症,8例慢性并发症。我们采用了以下手术方式:2例合并直肠癌患者均行全直肠结肠切除术,31例行全结肠切除术加回肠直肠吻合术(一期或二期手术),17例行保留肛门的全直肠结肠切除术(均为二期或三期手术)。对于急性疾病伴并发症,我们进行了全结肠切除术加末端回肠造口术、直肠残端闭合术或乙状结肠残端外置形成黏液瘘。急性并发症的严重程度并不足以证明使用姑息性手术如回肠造口术、结肠造口术或哈特曼手术是合理的,因为这些手术的死亡率高于急诊行全结肠切除术的术后死亡率。即使在择期手术中,当患者状况不佳、营养消耗大、服用大剂量类固醇或免疫抑制药物时,我们也更倾向于分期手术。全直肠结肠切除术仅用于合并直肠癌、严重肛周疾病、括约肌失禁的溃疡性结肠炎病例。当直肠残端炎症病变轻微时,可行全结肠切除术加回肠直肠吻合术。保留肛门的全直肠结肠切除术是UC的首选手术方式,其功能结果与全结肠切除术加回肠直肠吻合术相当,但具有治愈疾病的优势。总死亡率为12%(6例患者)。