[Pharmacological action of pseudoephedrine salicylate on the central nervous system of mice].

OBJECTIVE

To study the action of pseudoephedrine salicylate on the central nervous system of mice.

METHODS

Following the administration of pseudoephedrine salicylate at various dose levels and schedules, the alterations in general behavior and autonomic activities of the mice were recorded using photoelectric counter Type GJ-1, the changes in hypnotic action indices (sleep latency, sleep-lasting time) for the mice placed on pentobarbital in advance were observed, and the muscular clonic spasm of forefoot and neck muscles as well as the deaths from convulsions induced by previously given pentylenetrazol, nicotin and picrotoxin were observed and recorded respectively.

RESULTS

Pseudoephedrine salicylate (12.5, 25.0, 50.0, 100.0 mg/kg) administrated ip significantly inhibited the autonomic activities and the hypnotic action induced by previously given pentobarbital. Pseudoephedrine salicylate (100.0 mg/kg) given ip was noted to have synergistic effect on convulsions of the mice previously given pentylenetrazol and picrotoxin at subthreshold doses respectively, but no synergistic effect of pseudoephedrine salicylate (100 mg/kg) and nicotin (at subthreshold dose 0.018 mg/kg) was observed.

CONCLUSION

Pseudoephedrine salicylate has excited effect on the central nervous system of mice.