Yan Lin, Jin Shao-ju, Wang Rui, Jiang Yuan-xu, Liu Li-jun
Department of Pharmacology, Ningxia Medical College, Yinchuan 750004, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2004 Sep;35(5):665-7.
To study the action of pseudoephedrine salicylate on the central nervous system of mice.
Following the administration of pseudoephedrine salicylate at various dose levels and schedules, the alterations in general behavior and autonomic activities of the mice were recorded using photoelectric counter Type GJ-1, the changes in hypnotic action indices (sleep latency, sleep-lasting time) for the mice placed on pentobarbital in advance were observed, and the muscular clonic spasm of forefoot and neck muscles as well as the deaths from convulsions induced by previously given pentylenetrazol, nicotin and picrotoxin were observed and recorded respectively.
Pseudoephedrine salicylate (12.5, 25.0, 50.0, 100.0 mg/kg) administrated ip significantly inhibited the autonomic activities and the hypnotic action induced by previously given pentobarbital. Pseudoephedrine salicylate (100.0 mg/kg) given ip was noted to have synergistic effect on convulsions of the mice previously given pentylenetrazol and picrotoxin at subthreshold doses respectively, but no synergistic effect of pseudoephedrine salicylate (100 mg/kg) and nicotin (at subthreshold dose 0.018 mg/kg) was observed.
Pseudoephedrine salicylate has excited effect on the central nervous system of mice.
研究水杨酸伪麻黄碱对小鼠中枢神经系统的作用。
按不同剂量和给药方案给予水杨酸伪麻黄碱后，用GJ-1型光电计数器记录小鼠的一般行为和自主活动变化；观察预先给予戊巴比妥的小鼠催眠作用指标（睡眠潜伏期、睡眠时间）的改变；分别观察并记录预先给予戊四氮、烟碱和苦味毒所致小鼠前足和颈部肌肉阵挛性抽搐及惊厥死亡情况。
腹腔注射水杨酸伪麻黄碱（12.5、25.0、50.0、100.0mg/kg）可显著抑制自主活动及预先给予戊巴比妥所致的催眠作用。腹腔注射水杨酸伪麻黄碱（100.0mg/kg）对分别预先给予阈下剂量戊四氮和苦味毒的小鼠惊厥有协同作用，但未观察到水杨酸伪麻黄碱（100mg/kg）与烟碱（阈下剂量0.018mg/kg）之间的协同作用。
水杨酸伪麻黄碱对小鼠中枢神经系统有兴奋作用。
