Kersten W, Stollewerk D, von Wahl P G
Abteilung für Lungen- und Bronchialheilkunde/Allergologie, Krankenhaus Bethanien/Moers.
Pneumologie. 1992 Jan;46(1):26-31.
Clinical investigations of the effect of the acaricide product Acarosan shows in a large collective of patients beneficial results, whereby the patients are examined up to three months after sanitation. The remaining patients of this study are followed up one and two years after sanitation in open clinical trials. Without exception Acarex test values decrease highly significant after three months, indicating the effective elimination of the house dust mites by Acarosan treatment and consequently the reduction of the allergen containing excreta. The values increase after one year, but after a repetition of the Acarosan treatment they decrease again to the level reached after the first sanitation. The best results are achieved by sanitation of carpets, less favourable results are obtained by treating matresses and upholstered furniture. After sanitation all patients with monovalent house dust mite sensitization report an improvement of their symptoms (eyes, nose, bronchi) up to two years. Drug consumption is variable and decreases over all for up to two years. Peak flow meter values improve in the first year and even further more in the second year. The clinical improvement does not depend on sex, living area or former immunotherapy. During the two year observation period immunologic parameters do not change. 25.6% of the patients show a negative provocation test after the first year and 57% after the second year. Side effects due to the sanitation or signs of sensitization against Acarosan are not observed.
杀螨剂产品Acarosan效果的临床研究表明，在大量患者群体中取得了有益的结果，这些患者在清洁后接受了长达三个月的检查。本研究的其余患者在开放临床试验中于清洁后一年和两年进行随访。无一例外，三个月后Acarex测试值显著下降，表明Acarosan治疗有效消除了屋尘螨，从而减少了含过敏原的排泄物。一年后这些值会上升，但在重复使用Acarosan治疗后又会再次下降到首次清洁后达到的水平。清洁地毯能取得最佳效果，而处理床垫和软垫家具的效果则较差。清洁后，所有对屋尘螨单价致敏的患者报告其症状（眼睛、鼻子、支气管）改善长达两年。药物消耗量各不相同，总体上在长达两年的时间里有所减少。峰值流量计值在第一年有所改善，在第二年甚至进一步提高。临床改善情况与性别、居住区域或既往免疫治疗无关。在两年的观察期内，免疫参数没有变化。第一年25.6%的患者激发试验呈阴性，第二年为57%。未观察到清洁导致的副作用或对Acarosan的致敏迹象。
