Koshikawa N, Tatsunuma T, Furuya K, Seki K
Department of Psychiatry, National Defense Medical College, Saitama, Japan.
Prostaglandins Leukot Essent Fatty Acids. 1992 Jan;45(1):33-6. doi: 10.1016/0952-3278(92)90099-5.
We examined plasma PGF2 alpha, PGE, PGE2, TXB2 and 6-keto-PGF1 alpha at intervals throughout 3 menstrual cycles in 20 patients with PMS. Similar measurements throughout 1 menstrual cycle were made in 12 age-matched control women. The plasma concentration of PGF2 alpha in the late luteal phase was significantly lower in patients with PMS compared with that in the control subjects. The plasma concentrations of PGE in the middle follicular phase and middle luteal phase, PGE2 alpha in the middle follicular phase and TXB2 in the middle and late luteal phase were significantly higher in 20 patients compared with the values in the controls. A disturbance of PG metabolism may contribute to the etiology of PMS.
我们在20例经前综合征患者的3个月经周期内，定期检测其血浆中的前列腺素F2α（PGF2α）、前列腺素E（PGE）、前列腺素E2（PGE2）、血栓素B2（TXB2）和6-酮-前列腺素F1α（6-keto-PGF1α）。对12名年龄匹配的对照女性在1个月经周期内进行了类似检测。与对照受试者相比，经前综合征患者黄体晚期血浆PGF2α浓度显著降低。与对照组相比，20例患者卵泡中期和黄体中期的血浆PGE浓度、卵泡中期的血浆PGE2α浓度以及黄体中期和晚期的血浆TXB2浓度显著升高。前列腺素代谢紊乱可能是经前综合征病因的一个因素。
