Hussain S Y, O'Brien P M, De Souza V, Okonofua F, Dandona P
Academic Department of Obstetrics and Gynaecology, Royal Free Hospital School of Medicine, Hampstead, London.
Br J Obstet Gynaecol. 1990 May;97(5):397-401. doi: 10.1111/j.1471-0528.1990.tb01825.x.
Atrial natriuretic peptide (ANP) concentrations were determined by radioimmunoassay technique in 23 women, 11 women with premenstrual syndrome (PMS) and 12 comparable asymptomatic women. The asymptomatic women showed no change in ANP concentration during the menstrual cycle. In the PMS group ANP levels showed a significant fall in the midluteal phase compared to levels in the follicular phase. Throughout the cycle ANP concentrations were lower in the PMS group than in the comparison group. This difference was statistically significant in the early, mid and late luteal phases of the cycle. The lower ANP concentration in the PMS group in the luteal phases may indicate either a lower plasma volume or a decrease in the total body sodium content or both. These findings are contrary to those expected.
采用放射免疫分析技术测定了23名女性的心房利钠肽（ANP）浓度，其中11名患有经前综合征（PMS），12名无症状对照女性。无症状女性在月经周期中ANP浓度无变化。在PMS组中，与卵泡期相比，黄体中期ANP水平显著下降。在整个周期中，PMS组的ANP浓度低于对照组。这种差异在周期的黄体早期、中期和晚期具有统计学意义。PMS组黄体期较低的ANP浓度可能表明血浆容量较低或全身钠含量减少或两者兼有。这些发现与预期相反。
