Mann B J, Petri W A
Departments of Medicine and Microbiology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Parasitol Today. 1991 Jul;7(7):173-6. doi: 10.1016/0169-4758(91)90125-8.
To ask what is new in Entamoeba histolytica research, one need look no further than the surface of this protozoan parasite. In the past year the cloning and partial characterization of five different surface antigens have been reported, a remarkable result of international research efforts against amebiosis. One of these proteins is the first protective immunogen identified in the animal model of amebic liver abscess. Barbara Mann and William Petri review these recent results, propose a nomenclature for the gene family of E. histolytica galactose lectins and discuss the roles of the different surface proteins in adhesion.
若要问溶组织内阿米巴研究有哪些新进展,只需看看这种原生动物寄生虫的表面即可。过去一年里,已有关于五种不同表面抗原的克隆及部分特性描述的报道,这是国际抗阿米巴病研究努力取得的显著成果。其中一种蛋白质是在阿米巴肝脓肿动物模型中鉴定出的首个保护性免疫原。芭芭拉·曼和威廉·佩特里回顾了这些最新成果,提出了溶组织内阿米巴半乳糖凝集素基因家族的命名法,并讨论了不同表面蛋白在黏附中的作用。