Li E, Becker A, Stanley S L
Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110.
J Exp Med. 1988 May 1;167(5):1725-30. doi: 10.1084/jem.167.5.1725.
We compared the adherence of E. histolytica trophozoites with a panel of lectin-resistant CHO mutants with altered glycosylation patterns. Our results coupled with data from saccharide inhibition studies indicate that terminal N-acetyllactosamine units on Asn-linked complex type oligosaccharides provide the major determinants on the cellular receptor for E. histolytica adhesion.
我们将溶组织内阿米巴滋养体与一组具有改变的糖基化模式的凝集素抗性CHO突变体的黏附情况进行了比较。我们的结果以及来自糖类抑制研究的数据表明,N-连接复合型寡糖上的末端N-乙酰乳糖胺单元是溶组织内阿米巴黏附细胞受体的主要决定因素。