十二指肠胃泌素的释放特征
Characteristics of release of duodenal gastrin.
作者信息
Wesdorp R I, Funovics J M, Hirsch H, Fischer J E
出版信息
Am J Surg. 1977 Mar;133(3):280-4. doi: 10.1016/0002-9610(77)90529-3.
Duodenal gastrin release in the dog was studied after mucosal antrectomy with intact duodenal innervation, following which basal gastrin levels fell. Acetylcholine at pH 7 but not at pH 1.5 and insulin hypoglycemia but not 2-deoxyglucose release duodenal gastrin. Glycine (pH7), physiologic saline (pH 7), and balloon distention failed to release duodenal gastrin. These findings suggest differences in release characteristics between canine antral and duodenal gastrin, and point out species differences between man and dog in respect to release of duodenal gastrin.
在犬十二指肠神经支配完整的情况下进行黏膜胃窦切除术后，对犬十二指肠胃泌素的释放进行了研究，术后基础胃泌素水平下降。pH值为7时的乙酰胆碱可释放十二指肠胃泌素，而pH值为1.5时则不能；胰岛素低血糖可释放十二指肠胃泌素，而2-脱氧葡萄糖则不能。甘氨酸（pH值为7）、生理盐水（pH值为7）和气囊扩张均未能释放十二指肠胃泌素。这些发现表明犬胃窦和十二指肠胃泌素的释放特性存在差异，并指出在十二指肠胃泌素释放方面人与犬存在种属差异。
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