Nilsson G, Brodin K
Scand J Gastroenterol Suppl. 1979;54:84-6.
In extracts of the normal duodenum from dog minute amounts (2%) of gastrin are present compared to those extracted from the pyloric antrum (4). Despite that, basal levels of gastrin in plasma are not lowered when the antrum is surgically removed and test meal stimulation still significantly elevates the concentrations of plasma gastrin. When also the duodenal bulb is surgically removed basal gastrin levels decrease considerably and stimulation by a meal no longer raises the gastrin concentration in plasma (5). The related results suggest that extra-antral release of gastrin may take place under basal and stimulated conditions in dogs and that this release essentially occurs from the proximal portion of the duodenum, i.e. the duodenal bulb. Considering the low amounts of gastrin normally present in the duodenum of dog we found that levels of gastrin in plasma under basal and stimulated conditions after antrectomy surprisingly high and have therefore put forward the hypothesis that a compensatory increase in duodenal gastrin content takes place when the antrum is surgically removed (3). In the present study the relation between time following antrectomy and duodenal concentration of gastrin has been studied. In addition we also investigated how total gastrectomy influences the gastrin content of duodenum in dogs.
与从幽门窦提取的胃泌素相比，从犬正常十二指肠提取物中存在微量（2%）的胃泌素（4）。尽管如此，当手术切除胃窦时，血浆中胃泌素的基础水平并未降低，并且试餐刺激仍会显著提高血浆胃泌素的浓度。当手术切除十二指肠球部时，基础胃泌素水平也会显著降低，进餐刺激不再提高血浆中胃泌素的浓度（5）。相关结果表明，犬在基础和刺激条件下可能会发生胃窦外胃泌素释放，并且这种释放主要发生在十二指肠的近端部分，即十二指肠球部。考虑到犬十二指肠中正常存在的胃泌素量较低，我们发现胃窦切除术后基础和刺激条件下血浆中胃泌素水平出奇地高，因此提出了一个假设，即手术切除胃窦时十二指肠胃泌素含量会发生代偿性增加（3）。在本研究中，我们研究了胃窦切除术后的时间与十二指肠胃泌素浓度之间的关系。此外，我们还研究了全胃切除术对犬十二指肠胃泌素含量的影响。
