脊椎动物的伤害感受：参与动物慢性疼痛脊髓机制的关键受体。

Nociception in vertebrates: key receptors participating in spinal mechanisms of chronic pain in animals.

作者信息

Garry Emer M, Jones Emma, Fleetwood-Walker Susan M

机构信息

Centre for Neuroscience Research and Division of Veterinary Biomedical Sciences, The Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Summerhall, Edinburgh, EH9 1QH, UK.

出版信息

Brain Res Brain Res Rev. 2004 Oct;46(2):216-24. doi: 10.1016/j.brainresrev.2004.07.009.

DOI:10.1016/j.brainresrev.2004.07.009

PMID:15464209

Abstract

Our view of vertebrate nociceptive processing is ever changing with the discovery of novel molecules that differentially affect sensory responses to noxious and innocuous stimulation and might be involved specifically in chronic pain states. In order to understand the physiology of nociception and design novel analgesics for intractable chronic pain, it is essential to uncover precisely what changes occur between a normal nociceptive processing state and hypersensitive chronic pain states in the spinal cord following different types of injury. An important area of focus for future work in this area will be the cellular and molecular mechanisms of neuronal plasticity that occur.

摘要

随着新型分子的发现，我们对脊椎动物伤害性感受处理的看法不断变化，这些分子对有害和无害刺激的感觉反应有不同影响，可能特别涉及慢性疼痛状态。为了理解伤害性感受的生理学并设计针对顽固性慢性疼痛的新型镇痛药，准确揭示在不同类型损伤后脊髓中正常伤害性感受处理状态和超敏慢性疼痛状态之间发生了哪些变化至关重要。该领域未来工作的一个重要重点将是所发生的神经元可塑性的细胞和分子机制。