Inglis V, Soliman M K, Higuera Ciapara I, Richards R H
Institute of Aquaculture, University of Stirling.
Vet Rec. 1992 Jan 18;130(3):45-8. doi: 10.1136/vr.130.3.45.
The efficacy of amoxycillin in the control of laboratory induced Aeromonas salmonicida infection in Atlantic salmon parr was investigated. When given in the diet at a dose rate of 80 mg per kg bodyweight it was effective against both a moderate and severe challenge (with mortality rates in untreated groups of 75 per cent and 45 per cent). At 40 mg per kg it was effective against the moderate challenge only. The plasma levels in these regimens were 1.25 micrograms per ml and 0.3 to 0.6 micrograms per ml and the minimum inhibitory concentration of the challenge strain of A salmonicida was 0.6 micrograms per ml. The potential of the Charm radiobioassay system in detecting antibiotic residues in fish tissue was studied. The level of amoxycillin in muscle and bone from fish in mid-treatment at 80 mg per kg was 0.32 micrograms per ml. After a 12 day withdrawal period at 18 degrees C no residue was detected within the 0.005 micrograms per ml limit of this test.
研究了阿莫西林对实验室诱导的大西洋鲑鱼苗气单胞菌感染的控制效果。当以每千克体重80毫克的剂量添加到饲料中时，它对中度和重度感染均有效（未处理组的死亡率分别为75%和45%）。每千克体重40毫克时，仅对中度感染有效。这些给药方案下的血浆水平分别为每毫升1.25微克和每毫升0.3至0.6微克，气单胞菌攻击菌株的最低抑菌浓度为每毫升0.6微克。研究了Charm放射生物测定系统检测鱼组织中抗生素残留的潜力。在以每千克体重80毫克进行中期处理的鱼的肌肉和骨骼中，阿莫西林水平为每毫升0.32微克。在18摄氏度下经过12天的停药期后，在此测试每毫升0.005微克的限度内未检测到残留。
