Montanya Eduard
Endocrine Unit, Hospital Universitari Bellvitge, Feixa Llarga s/n, 08907 L'Hospitalet de Llobregat, Barcelona, Spain.
Curr Opin Biotechnol. 2004 Oct;15(5):435-40. doi: 10.1016/j.copbio.2004.08.011.
New sources of insulin-producing cells are needed to overcome the limited availability of islet tissue for transplantation to diabetic patients. The engineering of murine or human transformed beta-cell lines and of non beta-cells has progressed slowly in recent years, while significant achievements have been claimed in the differentiation of insulin-producing cells from embryonic and adult stem cells. Some of the results have been questioned, however, and the generated cells lack many characteristics of differentiated beta-cells. A much better understanding of the processes that govern the expansion and differentiation of stem cells is needed.
需要新的胰岛素产生细胞来源，以克服用于移植给糖尿病患者的胰岛组织供应有限的问题。近年来，小鼠或人类转化β细胞系以及非β细胞的工程进展缓慢，而在从胚胎干细胞和成体干细胞分化产生胰岛素产生细胞方面则取得了显著成果。然而，其中一些结果受到了质疑，并且所产生的细胞缺乏分化β细胞的许多特征。我们需要更好地理解控制干细胞增殖和分化的过程。
