Bhattacharya Sanjoy K
Department of Ophthalmic Research, I31 Cleveland Clinic Foundation, Ohio 44195, USA.
Curr Opin Biotechnol. 2004 Oct;15(5):449-55. doi: 10.1016/j.copbio.2004.08.012.
Biocatalysis is currently employed to produce known substances more economically and for the synthesis of new compounds. Increased production or novel product synthesis can be achieved through the use of mutant organisms, tailored enzymes or novel combinations of enzymes in reactors. These complex biosyntheses, once only in the realm of the biopharmaceutical industry, have now been embraced by the food and textile industries and are finding geochemical and environmental applications. New uses are dictating novel methods of manufacture that utilize knowledge of systems level biology. Increased understanding of the functional interaction of proteins and protein-protein networks is also altering the practice of in vitro biosynthesis.
生物催化目前用于更经济地生产已知物质以及合成新化合物。通过使用突变生物体、定制酶或在反应器中使用酶的新型组合，可以提高产量或合成新产品。这些复杂的生物合成曾经仅存在于生物制药行业领域，现在已被食品和纺织行业所采用，并正在应用于地球化学和环境领域。新的用途正在催生出利用系统生物学知识的新型制造方法。对蛋白质和蛋白质-蛋白质网络功能相互作用的深入理解也正在改变体外生物合成的实践。
