Tekgul Hasan, Polat Muzaffer, Serdaroğlu Gul, Ikizoğlu Tarkan, Yalaz Mehmet, Kutukculer Necil, Gökben Sarenur
Department of Pediatrics, Division of Pediatric Neurology, Ege University Hospital, Bornova-Izmir 35100, Turkey.
Pediatr Neurol. 2004 Oct;31(4):258-60. doi: 10.1016/j.pediatrneurol.2004.05.003.
The aim of this prospective study is to define the prognostic significance of lymphocyte subset analysis in children with Bell's palsy. Lymphocyte subgroup analysis in peripheral blood was performed in 17 children with Bell's palsy by using flow cytometry. Before a standard protocol of corticosteroid treatment, patients were categorized into two groups for facial nerve impairment on the basis of the clinical findings: Group 1 (mild to moderate impairment), 7 patients; and Group 2 (severe impairment), 10 patients. Outcome of the patients was evaluated at the end of 3 months follow-up and categorized as satisfactory recovery (n = 12) or unsatisfactory recovery (n = 5). Decreased percentages of B cells (CD19) and T helper/inducer (CD4) subsets were measured in patients with Bell's palsy compared with age-matched healthy control patients. Patients with severe impairment had significantly lower percentages of CD4 and CD19 subsets, whereas patients with mild to moderate impairment had only decreased percentage of CD19 subsets. There was no statistically significant difference in the percentage of lymphocyte subsets between the patients with satisfactory and unsatisfactory recovery. These results provide additional support for cell-mediated immunopathogenesis in patients with Bell's palsy, without any prognostic significance for the outcome.
这项前瞻性研究的目的是确定淋巴细胞亚群分析在贝尔面瘫患儿中的预后意义。采用流式细胞术对17例贝尔面瘫患儿进行外周血淋巴细胞亚群分析。在采用标准皮质类固醇治疗方案之前，根据临床检查结果将患者分为面神经损伤两组：第1组（轻度至中度损伤），7例患者；第2组（重度损伤），10例患者。在3个月随访结束时评估患者的预后，并分为恢复良好（n = 12）或恢复不佳（n = 5）。与年龄匹配的健康对照患者相比，贝尔面瘫患者的B细胞（CD19）和辅助性/诱导性T细胞（CD4）亚群百分比降低。重度损伤患者的CD4和CD19亚群百分比显著较低，而轻度至中度损伤患者仅CD19亚群百分比降低。恢复良好和恢复不佳的患者之间淋巴细胞亚群百分比无统计学显著差异。这些结果为贝尔面瘫患者的细胞介导免疫发病机制提供了额外支持，但对预后无任何意义。
