Losi Maria-Angela, Betocchi Sandro, Aversa Mariano, Lombardi Raffaella, Miranda Marianna, D'Alessandro Gianluigi, Cacace Alessandra, Tocchetti Carlo-Gabriele, Barbati Giovanni, Chiariello Massimo
Department of Clinical Medicine, Cardiovascular and Immunological Sciences, Federico II University School of Medicine, Naples, Italy.
Am J Cardiol. 2004 Oct 1;94(7):895-900. doi: 10.1016/j.amjcard.2004.06.024.
Predictors of the development of atrial fibrillation (AF) in patients who have hypertrophic cardiomyopathy (HC) have not been extensively studied, although, in these patients, AF contributes to the exacerbation of symptoms and the development of heart failure. The present study determined the role of left atrial (LA) function in the development of AF in patients who have HC. One hundred fifty consecutive patients who had HC, had no history of AF, and who were followed for 5.2 +/- 2.9 years constituted the study population. Using M-mode echocardiography, we measured LA function as global LA fractional shortening and LA diameter. LA volume was measured from 2-dimensional 4-chamber views by the method of disks. During follow-up, 20 patients developed AF. LA function was an independent predictor of AF (odds ratio 0.716, p = <0.001), whereas LA diameter and volume were predictors in addition to age. Kaplan-Meier analysis showed that LA dysfunction carried a high risk of AF. Thus, in patients who have HC, LA function is a strong predictor of AF development and is independent of age.
肥厚型心肌病（HC）患者发生心房颤动（AF）的预测因素尚未得到广泛研究，尽管在这些患者中，AF会导致症状加重和心力衰竭的发生。本研究确定了左心房（LA）功能在HC患者发生AF中的作用。连续纳入150例HC患者，这些患者无AF病史，随访时间为5.2±2.9年，构成研究人群。使用M型超声心动图，我们将LA功能测量为整体LA缩短分数和LA直径。通过圆盘法从二维四腔视图测量LA容积。在随访期间，20例患者发生了AF。LA功能是AF的独立预测因素（比值比0.716，p =<0.001），而LA直径和容积除年龄外也是预测因素。Kaplan-Meier分析表明，LA功能障碍具有较高的AF风险。因此，在HC患者中，LA功能是AF发生的强有力预测因素，且独立于年龄。
