Conversi D, Orsini C, Cabib S
Department of Psychology, University La Sapienza, via dei Marsi 78, Rome 00185, Italy.
Brain Res. 2004 Oct 29;1025(1-2):59-66. doi: 10.1016/j.brainres.2004.07.072.
Mice from the inbred strains C57BL/6 and DBA/2 are characterized by striking differences in their behavioral response to addictive drugs. We used Fos expression as a tool to reveal strain differences in the postsynaptic effects of amphetamine (AMPH; 2.5 mg/kg) within the nucleus accumbens (NAc) (core and shell) and the dorsal caudate (dorsomedial and dorsolateral). AMPH stimulated Fos expression in all striatal regions of mice from both strains. However, while C57BL/6 showed a higher Fos response than DBA/2 mice in both NAc shell and core, the opposite was true for the dorsolateral caudate. The effects of AMPH were prevented by D1 blockade in all striatal regions of both strains and mimicked by the D1 agonist, SKF82958 (0.1 mg/kg), in both regions of the caudate and in the NAc shell, but not in the core. Our results suggest that the functional heterogeneity of the striatal complex is under genetic control and that this control may implicate DA transmission and corticostriatal interactions.
近交系C57BL/6和DBA/2小鼠对成瘾药物的行为反应存在显著差异。我们使用Fos表达作为一种工具，来揭示伏隔核（NAc）（核心和壳）以及背侧尾状核（背内侧和背外侧）中苯丙胺（AMPH；2.5mg/kg）突触后效应的品系差异。AMPH刺激了两个品系小鼠所有纹状体区域的Fos表达。然而，虽然C57BL/6小鼠在NAc壳和核心区域的Fos反应高于DBA/2小鼠，但在背外侧尾状核中情况则相反。AMPH的作用在两个品系的所有纹状体区域均被D1阻断所抑制，并且在尾状核的两个区域以及NAc壳中被D1激动剂SKF82958（0.1mg/kg）模拟，但在核心区域未被模拟。我们的结果表明，纹状体复合体的功能异质性受遗传控制，并且这种控制可能涉及多巴胺传递和皮质纹状体相互作用。
