Jamal A, Kalantari R
OB/GYN Department, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Int J Gynaecol Obstet. 2004 Oct;87(1):6-8. doi: 10.1016/j.ijgo.2004.06.004.
To compare the efficacy and safety of high dose oxytocin in the augmentation of labor.
Two hundred pregnant women requiring augmentation of labor were randomly assigned to receive oxytocin by either a low dose protocol (1.5 microm/min initially, increased by 1.5 microm/min every 30 min) or a high dose protocol (4.5 microm/min initially, increased by 4.5 microm/min every 30 min).
High dose of oxytocin was associated with a significant shortening of labor 4 (1.10-10) vs. 6 (1-10) h, p<0.0001 without a significant difference in cesarean delivery rate, neonatal and maternal outcome.
The use of high dose oxytocin is associated with significantly shorter labor without any adverse fetal and maternal effects.
比较高剂量缩宫素用于引产的有效性和安全性。
200名需要引产的孕妇被随机分配，分别接受低剂量方案（初始剂量为1.5微克/分钟，每30分钟增加1.5微克/分钟）或高剂量方案（初始剂量为4.5微克/分钟，每30分钟增加4.5微克/分钟）的缩宫素治疗。
高剂量缩宫素组的产程显著缩短，为4（1.10 - 10）小时，而低剂量组为6（1 - 10）小时，p<0.0001，剖宫产率、新生儿及产妇结局无显著差异。
使用高剂量缩宫素可显著缩短产程，且对胎儿和产妇无不良影响。
