An Seong, Zenisek David
Yale University School of Medicine, Department of Cellular and Molecular Physiology, Sterling Hall of Medicine, B-147, 333 Cedar St, New Haven, Connecticut 06520, USA.
Curr Opin Neurobiol. 2004 Oct;14(5):522-30. doi: 10.1016/j.conb.2004.08.008.
Neurons communicate with one another through the release of molecules from synaptic vesicles and large dense core granules through the process of exocytosis. During exocytosis, molecules are released to the extracellular space through a fusion pore, which can either dilate, resulting in full fusion, or close, resulting in incomplete exocytosis, often referred to as 'kiss and run' exocytosis. Recently, there has been much interest in the regulation of this process in both neurons and neuroendocrine cells. There has been much recent work that addresses the existence of incomplete exocytosis in neurons and neuroendocrine cells, as well as recent work probing the molecular components and modulation of the fusion pore.
神经元通过胞吐作用从突触小泡和大致密核心颗粒中释放分子，从而彼此进行通讯。在胞吐过程中，分子通过融合孔释放到细胞外空间，融合孔可以扩张，导致完全融合，也可以关闭，导致不完全胞吐，通常称为“亲吻并跑”式胞吐。最近，人们对神经元和神经内分泌细胞中这一过程的调节产生了浓厚兴趣。最近有许多工作涉及神经元和神经内分泌细胞中不完全胞吐的存在，以及探索融合孔的分子成分和调节的最新研究。
