神经递质的树突释放
Dendritic Release of Neurotransmitters.
作者信息
Ludwig Mike, Apps David, Menzies John, Patel Jyoti C, Rice Margaret E
机构信息
Centre for Integrative Physiology, University of Edinburgh, Edinburgh, United Kingdom.
Department of Neurosurgery, New York University School of Medicine, New York, USA.
出版信息
Compr Physiol. 2016 Dec 6;7(1):235-252. doi: 10.1002/cphy.c160007.
Abstract
Release of neuroactive substances by exocytosis from dendrites is surprisingly widespread and is not confined to a particular class of transmitters: it occurs in multiple brain regions, and includes a range of neuropeptides, classical neurotransmitters, and signaling molecules, such as nitric oxide, carbon monoxide, ATP, and arachidonic acid. This review is focused on hypothalamic neuroendocrine cells that release vasopressin and oxytocin and midbrain neurons that release dopamine. For these two model systems, the stimuli, mechanisms, and physiological functions of dendritic release have been explored in greater detail than is yet available for other neurons and neuroactive substances. © 2017 American Physiological Society. Compr Physiol 7:235-252, 2017.
摘要
神经活性物质通过树突胞吐作用释放的现象惊人地普遍，并不局限于某一类递质：它发生在多个脑区，包括一系列神经肽、经典神经递质以及信号分子，如一氧化氮、一氧化碳、三磷酸腺苷和花生四烯酸。本综述聚焦于释放血管加压素和催产素的下丘脑神经内分泌细胞以及释放多巴胺的中脑神经元。对于这两个模型系统，树突释放的刺激因素、机制和生理功能已得到比其他神经元和神经活性物质更详细的研究。© 2017美国生理学会。《综合生理学》7:235 - 252, 2017。
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