Prère M-F, Licznar P, Decramer S, Fayet O
Laboratoire de microbiologie et génétique moléculaires (LMGM), IBCG, CNRS, université Paul-Sabatier, 118, route de Narbonne, Toulouse 31062 cedex, France.
Pathol Biol (Paris). 2004 Oct;52(8):497-500. doi: 10.1016/j.patbio.2004.07.035.
E. coli remains the most often isolated pathogen in community urinary tract infections in children. We reported a retrospective study of antibiotic susceptibility of 506 E. coli strains isolated from urine. We found that 53% of the strains were resistant to amoxicilline and 22% to cotrimoxazole. The frequency of resistance to amoxicillin-clavulanic acid was of 7%, 40% of the strains were just intermediary and 53% were sensitive. Only five strains (1%) were resistant to ceftazidime: two mechanisms of resistance, hyperproduction of TEM betalactamase (3 cases) and cephalosporinase (2 cases), were suggested. This study illustrates the necessity of constant monitoring of bacterial resistance to adapt antibiotherapeutic guidelines to local evolution.
大肠杆菌仍然是儿童社区获得性尿路感染中最常分离出的病原体。我们报告了一项对从尿液中分离出的506株大肠杆菌进行抗生素敏感性的回顾性研究。我们发现，53%的菌株对阿莫西林耐药，22%对复方新诺明耐药。对阿莫西林-克拉维酸的耐药率为7%，40%的菌株仅为中介，53%敏感。仅5株（1%）对头孢他啶耐药：提示了两种耐药机制，即TEMβ-内酰胺酶高产（3例）和头孢菌素酶（2例）。本研究说明了持续监测细菌耐药性以根据当地情况调整抗菌治疗指南的必要性。
