巴西卡地菌素B-D，来自巴西诺卡氏放线菌的新型三环萜类化合物[萜类化合物的校正] 。
Brasilicardins B-D, new tricyclic terpenoids [correction of terpernoids] from actinomycete Nocardia brasiliensis.
作者信息
Komatsu Kazusei, Tsuda Masashi, Shiro Motoo, Tanaka Yasushi, Mikami Yuzuru, Kobayashi Jun'ichi
机构信息
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
出版信息
Bioorg Med Chem. 2004 Nov 1;12(21):5545-51. doi: 10.1016/j.bmc.2004.08.007.
Three new tricyclic terpenoids, brasilicardins B-D (2-4), were isolated together with brasilicardin A (1), a potent immunosuppressive compound, from the cultured broth of a pathogenic actinomycete Nocardia brasiliensis IFM0406, and the structures and stereochemistry were determined by spectroscopic data and a single crystal X-ray diffraction analysis. The immunosuppressive and cytotoxic activities of 2-4 were examined in the comparison with 1.
从致病性放线菌巴西诺卡氏菌IFM0406的培养液中分离出三种新的三环萜类化合物，即巴西卡汀B-D（2-4），同时还分离出了具有强效免疫抑制作用的化合物巴西卡汀A（1），并通过光谱数据和单晶X射线衍射分析确定了它们的结构和立体化学。将2-4的免疫抑制和细胞毒性活性与1进行了比较研究。
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