豚鼠诺卡氏菌IFM 10152的全基因组序列。
The complete genomic sequence of Nocardia farcinica IFM 10152.
作者信息
Ishikawa Jun, Yamashita Atsushi, Mikami Yuzuru, Hoshino Yasutaka, Kurita Haruyo, Hotta Kunimoto, Shiba Tadayoshi, Hattori Masahira
机构信息
Department of Bioactive Molecules, National Institute of Infectious Diseases, Shinjuku, Tokyo 162-8640, Japan.
出版信息
Proc Natl Acad Sci U S A. 2004 Oct 12;101(41):14925-30. doi: 10.1073/pnas.0406410101. Epub 2004 Oct 4.
Abstract
We determined the genomic sequence of Nocardia farcinica IFM 10152, a clinical isolate, and revealed the molecular basis of its versatility. The genome consists of a single circular chromosome of 6,021,225 bp with an average G+C content of 70.8% and two plasmids of 184,027 (pNF1) and 87,093 (pNF2) bp with average G+C contents of 67.2% and 68.4%, respectively. The chromosome encoded 5,674 putative protein-coding sequences, including many candidate genes for virulence and multidrug resistance as well as secondary metabolism. Analyses of paralogous protein families suggest that gene duplications have resulted in a bacterium that can survive not only in soil environments but also in animal tissues, resulting in disease.
摘要
我们测定了临床分离株嗜皮疽诺卡氏菌IFM 10152的基因组序列，并揭示了其多功能性的分子基础。该基因组由一条6,021,225 bp的单环状染色体组成，平均G+C含量为70.8%，以及两个质粒，分别为184,027 bp（pNF1）和87,093 bp（pNF2），平均G+C含量分别为67.2%和68.4%。染色体编码了5,674个推定的蛋白质编码序列，包括许多毒力、多药耐药性以及次生代谢的候选基因。对旁系同源蛋白家族的分析表明，基因复制产生了一种不仅能在土壤环境中生存，还能在动物组织中生存并导致疾病的细菌。
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