某些抗精神病药物对偏执型精神分裂症患者红细胞镁及血浆镁、钙、铜和锌的影响。
The influence of some antipsychotics on erythrocyte magnesium and plasma magnesium, calcium, copper and zinc in patients with paranoid schizophrenia.
作者信息
Nechifor Mihai, Vaideanu C, Palamaru I, Borza C, Mindreci I
机构信息
Department of Pharmacology, University of Medicine and Pharmacy, Gr. T. Popa Iaśi, Str. Universită'tii nr. 16, Iaśi 700115, Romania.
出版信息
J Am Coll Nutr. 2004 Oct;23(5):549S-551S. doi: 10.1080/07315724.2004.10719401.
OBJECTIVE
The aim of the study was the investigation of plasma magnesium, calcium, copper and zinc and erythrocyte magnesium levels in patients with paranoid schizophrenia and the influence of the therapy with two antipsychotic drugs (haloperidol and risperidone) on these concentrations.
METHODS
We investigated the influence of treatment with haloperidol and risperidoneon plasma and erythrocyte magnesium and on plasmatic levels of zinc, calcium and copper on hospitalized 56 patients diagnosed with paranoid schizophrenia (DSM IV).
RESULTS
Our data indicate a decrease of erythrocyte magnesium levels in schizophrenic patients (4.82 +/- 3.1 mg/L vs. 59.2 +/- 1.1 mg/L in control group, p < 0.01). The plasma level of magnesium was unchanged (18.9 +/- 2.17 mg/L in schizophrenic patients vs. 18.26 +/- 1.9 mg/L in control group).
CONCLUSIONS
We consider plasma Cu(2+)/erythrocyte Mg(2+) and plasma Cu(2+)/Zn(2+) ratio two important biological markers of the acute paranoid schizophrenia.
目的
本研究旨在调查偏执型精神分裂症患者的血浆镁、钙、铜和锌以及红细胞镁水平，以及两种抗精神病药物（氟哌啶醇和利培酮）治疗对这些浓度的影响。
方法
我们调查了氟哌啶醇和利培酮治疗对56例住院诊断为偏执型精神分裂症（DSM-IV）患者的血浆和红细胞镁以及血浆锌、钙和铜水平的影响。
结果
我们的数据表明，精神分裂症患者的红细胞镁水平降低（4.82±3.1mg/L，对照组为59.2±1.1mg/L，p<0.01）。血浆镁水平未改变（精神分裂症患者为18.9±2.17mg/L，对照组为18.26±1.9mg/L）。
结论
我们认为血浆铜离子/红细胞镁离子和血浆铜离子/锌离子比值是急性偏执型精神分裂症的两个重要生物学标志物。
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