Iskra M, Patelski J, Majewski W
Department of General Chemistry, K. Marcinkowski Academy of Medicine, Poznań, Poland.
J Trace Elem Electrolytes Health Dis. 1993 Sep;7(3):185-8.
The concentrations of calcium, magnesium, zinc, copper, free fatty acids and total, HDL- and LDL-cholesterol in the sera of atherosclerotic men were determined. The subjects with femoral atherosclerosis were divided into two age groups: 35-59 years (N = 8, I) and 60-75 years (N = 8, II). The LDL-cholesterol concentration was increased in the elderly atherosclerotic group. Lower concentrations of calcium and magnesium, a higher concentration of copper and decreased Ca/Cu, Mg/Zn, Mg/Cu and Zn/Cu ratios were found in atherosclerosis I as compared to controls of the same age. High and positive correlations for Cu vs. total cholesterol and LDL-cholesterol (r > 0.89), but low correlation for Cu vs. HDL-cholesterol (r = 0.61) were calculated in atherosclerosis I, and negative correlations for free fatty acids vs. Ca and Mg (-r > 0.77) in atherosclerosis II.
测定了动脉粥样硬化男性血清中钙、镁、锌、铜、游离脂肪酸以及总胆固醇、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇的浓度。患有股动脉粥样硬化的受试者被分为两个年龄组：35 - 59岁（N = 8，I组）和60 - 75岁（N = 8，II组）。老年动脉粥样硬化组的低密度脂蛋白胆固醇浓度升高。与同年龄对照组相比，I组动脉粥样硬化患者的钙和镁浓度较低，铜浓度较高，且钙/铜、镁/锌、镁/铜和锌/铜比值降低。在I组动脉粥样硬化患者中，计算得出铜与总胆固醇和低密度脂蛋白胆固醇呈高度正相关（r > 0.89），但铜与高密度脂蛋白胆固醇的相关性较低（r = 0.61）；在II组动脉粥样硬化患者中，游离脂肪酸与钙和镁呈负相关（-r > 0.77）。
