Malavige G N, Fernando S, Fernando D J, Seneviratne S L
Department of Clinical Immunology, A Floor, West Block, Queens Medical Centre, University Hospital, Nottingham NG7 2UH, UK.
Postgrad Med J. 2004 Oct;80(948):588-601. doi: 10.1136/pgmj.2004.019638.
Dengue viral infections are one of the most important mosquito borne diseases in the world. They may be asymptomatic or may give rise to undifferentiated fever, dengue fever, dengue haemorrhagic fever (DHF), or dengue shock syndrome. Annually, 100 million cases of dengue fever and half a million cases of DHF occur worldwide. Ninety percent of DHF subjects are children less than 15 years of age. At present, dengue is endemic in 112 countries in the world. No vaccine is available for preventing this disease. Early recognition and prompt initiation of appropriate treatment are vital if disease related morbidity and mortality are to be limited. This review outlines aspects of the epidemiology of dengue infections, the dengue virus and its mosquito vector, clinical features and pathogenesis of dengue infections, and the management and control of these infections.
登革病毒感染是世界上最重要的蚊媒疾病之一。它们可能无症状，也可能引发未分化热、登革热、登革出血热（DHF）或登革休克综合征。全球每年有1亿例登革热病例和50万例登革出血热病例。90%的登革出血热患者为15岁以下儿童。目前，登革热在世界上112个国家流行。尚无预防该疾病的疫苗。若要限制与疾病相关的发病率和死亡率，早期识别并及时开始适当治疗至关重要。本综述概述了登革病毒感染的流行病学、登革病毒及其蚊媒、登革病毒感染的临床特征和发病机制，以及这些感染的管理和控制。
