Kumar Kaushalendra, Tripathi Amit Kumar, Sharma Vikas Kumar, Mishra Sunil Kumar, Patnaik Ranjana
School of Biomedical Science, Galgotias University, Greater Noida, India.
Department of Statistics, Banaras Hindu University, Varanasi, 221005, India.
Infect Disord Drug Targets. 2025;25(4):e18715265315051. doi: 10.2174/0118715265315051241017044129.
Acute febrile illness (AFI) is a frequent occurrence in India, often complicated by a multitude of pathogenic and etiological factors. In this context, it is important to analyze the biochemical, hematological, and epidemiological clinical parameters of AFI patients in the North Indian population.
This study included 1,819 patients of various ages who presented with new-onset acute febrile illness (AFI) between 2017 and 2021. Among these patients, 211, with a median age of 40 years (ranging from 2 to 85 years), were selected for further analysis. At enrollment, clinical examination involved collecting respiratory tract specimens, blood, and urine samples for biochemical analysis, with subsequent data analysis conducted using statistical methods.
The following biochemical parameters were analyzed: C-reactive protein (CRP), alkaline phosphatase (ALP), serum glutamate-pyruvate transaminase (SGPT), serum glutamic oxaloacetic transaminase (SGOT), gamma-glutamyl transpeptidase (GGT), and total protein serum. The hematological parameters included total leukocyte count (TLC), lymphocyte count, monocyte count, eosinophil count, red blood cell count (RBCs), packed cell volume (PCV), erythrocyte sedimentation rate (ESR), hematocrit value, mean corpuscular volume (MCV), and mean corpuscular hemoglobin (MCH). Additionally, clinical parameters such as phosphorus, urea, calcium, sodium, uric acid, bilirubin, and potassium were measured. Specific values observed were: SGPT (113 IU/L in 2018), SGOT (81 U/L in 2019), GGT (148 g/L in 2018), and total protein serum (7 g/L in 2020). The hematological parameters (TLC, lymphocyte, monocyte, RBCs, PCV, ESR, MCV, and MCH). The regression analysis was conducted to explore the temperature recorded at the time of admission, the duration of hospital stays, and biochemical as well as hematological variables of patients suffering from AFI. Karl-Pearson's correlation coefficient and variance inflation factor for each variable mentioned above.
Biochemical and hematological parameters were analyzed over different years of intake in patients with Acute Febrile Illness (AFI). Further investigation is required to explore the mechanistic pathways of infection, and preventive measures will be implemented using natural products and other therapeutic interventions. Our data will offer the first systematic assessment of the etiological factors, along with regression analysis and the Karl-Pearson correlation coefficient for each variable in AFI patients.
急性发热性疾病（AFI）在印度很常见，常常因多种致病和病因因素而复杂化。在这种背景下，分析北印度人群中AFI患者的生化、血液学和流行病学临床参数很重要。
本研究纳入了2017年至2021年间出现新发急性发热性疾病（AFI）的1819名不同年龄段的患者。在这些患者中，选取了211名年龄中位数为40岁（年龄范围为2至85岁）的患者进行进一步分析。在入组时，临床检查包括采集呼吸道标本、血液和尿液样本进行生化分析，随后使用统计方法进行数据分析。
分析了以下生化参数：C反应蛋白（CRP）、碱性磷酸酶（ALP）、血清谷丙转氨酶（SGPT）、血清谷草转氨酶（SGOT）、γ-谷氨酰转肽酶（GGT）和血清总蛋白。血液学参数包括白细胞总数（TLC）、淋巴细胞计数、单核细胞计数、嗜酸性粒细胞计数、红细胞计数（RBCs）、红细胞压积（PCV）、红细胞沉降率（ESR）、血细胞比容值、平均红细胞体积（MCV）和平均红细胞血红蛋白含量（MCH）。此外，还测量了磷、尿素、钙、钠、尿酸、胆红素和钾等临床参数。观察到的具体数值为：SGPT（2018年约为113 IU/L）、SGOT（2019年约为81 U/L）、GGT（2018年约为148 g/L）和血清总蛋白（2020年约为7 g/L）。血液学参数（TLC、淋巴细胞、单核细胞、RBCs、PCV、ESR、MCV和MCH）。进行回归分析以探究入院时记录的体温、住院时间以及AFI患者的生化和血液学变量。上述每个变量的卡尔 - 皮尔逊相关系数和方差膨胀因子。
对急性发热性疾病（AFI）患者不同入院年份的生化和血液学参数进行了分析。需要进一步研究以探索感染的机制途径，并将使用天然产物和其他治疗干预措施实施预防措施。我们的数据将提供对病因因素的首次系统评估，以及AFI患者中每个变量的回归分析和卡尔 - 皮尔逊相关系数。
