Coşkun Nurten, Demir Ranya, Canbolat Ahmet Alperen, Sarıtaş Sümeyye, Pekdemir Burcu, Bechelany Mikhael, Karav Sercan
Department of Molecular Biology and Genetics, Çanakkale Onsekiz Mart University, Çanakkale 17000, Türkiye.
Institut Européen des Membranes (IEM), Centre National de la Recherche Scientifique (CNRS), École Nationale Supérieure de Chimie de Montpellier (ENSCM), Unité Mixte de Recherche (UMR) 5635, University Montpellier, F-34095 Montpellier, France.
Nutrients. 2025 Jul 16;17(14):2325. doi: 10.3390/nu17142325.
Polyphenols are structurally diverse plant metabolites that have attracted significant interest. Their compositions are versatile, depending on their structures, including the number of rings in the polyphenol composition. Based on these attributes, polyphenols can be classified as flavanols, anthocyanins, flavones, phenolic acids, stilbenes, and lignans. Polyphenols mainly possess inhibition of viral replication, interference with viral protein synthesis, and modulation of immune responses, providing significant antiviral effects against several viruses, including herpes simplex virus, hepatitis C virus, and influenza. They are crucial for medical compounds in diverse, versatile treatments, namely in diabetes, cardiovascular disorders, cancer, and neurodegenerative problems. Plants are the primary source of bioactive molecules, which are valued for their anti-inflammatory, antioxidant, anticancer, and antiviral activities. Especially, polyphenols are extracted as the most abundant bioactive compounds of plants. Moreover, viral infections are one of the major factors in illnesses and diseases, along with bacteria and fungi. Numerous in vitro and in vivo studies report antiviral activity against SARS-CoV-2, Mayaro virus, dengue virus, herpesvirus, and influenza A virus, though clinical validation remains limited. Additionally, inhibition of viral entry, interference with viral replication, modulation of host immune response, and direct virucidal effects were examined.
多酚是结构多样的植物代谢产物，已引起广泛关注。其组成多种多样，取决于其结构，包括多酚组成中的环数。基于这些特性，多酚可分为黄烷醇、花青素、黄酮、酚酸、芪类和木脂素。多酚主要具有抑制病毒复制、干扰病毒蛋白合成以及调节免疫反应的作用，对包括单纯疱疹病毒、丙型肝炎病毒和流感病毒在内的多种病毒具有显著的抗病毒效果。它们在糖尿病、心血管疾病、癌症和神经退行性疾病等多种治疗中对于医用化合物至关重要。植物是生物活性分子的主要来源，这些分子因其抗炎、抗氧化、抗癌和抗病毒活性而受到重视。特别是，多酚是从植物中提取的最丰富的生物活性化合物。此外，病毒感染与细菌和真菌一样，是疾病的主要因素之一。众多体外和体内研究报告了对严重急性呼吸综合征冠状病毒2、马亚罗病毒、登革热病毒、疱疹病毒和甲型流感病毒的抗病毒活性，不过临床验证仍然有限。此外，还研究了对病毒进入的抑制、对病毒复制的干扰、对宿主免疫反应的调节以及直接杀病毒作用。
