Kilduff L P, Georgiades E, James N, Minnion R H, Mitchell M, Kingsmore D, Hadjicharlambous M, Pitsiladis Y P
Centre for Exercise Science and Medicine in the Institute of Biomedical and Life Sciences at the University of Glasgow, Glasgow, UK.
Int J Sport Nutr Exerc Metab. 2004 Aug;14(4):443-60. doi: 10.1123/ijsnem.14.4.443.
The effects of creatine (Cr) supplementation on cardiovascular, metabolic, and thermoregulatory responses, and on the capacity of trained humans to perform prolonged exercise in the heat was examined. Endurance-trained males (n = 21) performed 2 constant-load exercise tests to exhaustion at 63 +/- 5 % VO(2max) in the heat (ambient temperature: 30.3 +/- 0.5 C) before and after 7 d of Cr (20 g x d (-1 ) Cr + 140 g x d (-1 ) glucose polymer) or placebo. Cr increased intracellular water and reduced thermoregulatory and cardiovascular responses (e.g., heart rate, rectal temperature, sweat rate) but did not significantly increase time to exhaustion (47.0 +/-4.7 min vs. 49.7 +/- 7.5 min, P =0.095). Time to exhaustion was increased significantly in subjects whose estimated intramuscular Cr levels were substantially increased ("responders" : 47.3 +/- 4.9 min vs. 51.7 +/- 7.4 min, P = 0.031). Cr-induced hyperhydration can result in a more efficient thermoregulatory response during prolonged exercise in the heat.
研究了补充肌酸（Cr）对心血管、代谢和体温调节反应的影响，以及对训练有素的人在高温环境下进行长时间运动能力的影响。耐力训练的男性（n = 21）在补充Cr（20 g·d⁻¹ Cr + 140 g·d⁻¹葡萄糖聚合物）或安慰剂7天前后，于高温环境（环境温度：30.3 ± 0.5℃）下进行了两次63 ± 5% VO₂max的恒定负荷运动测试直至 exhaustion。Cr增加了细胞内水分，降低了体温调节和心血管反应（如心率、直肠温度、出汗率），但并未显著增加运动至 exhaustion的时间（47.0 ± 4.7分钟对49.7 ± 7.5分钟，P = 0.095）。在估计肌肉内Cr水平大幅增加的受试者（“反应者”）中，运动至 exhaustion的时间显著增加（47.3 ± 4.9分钟对51.7 ± 7.4分钟，P = 0.031）。Cr诱导的高水合作用可在高温环境下长时间运动期间导致更有效的体温调节反应。
