Mukhopadhyay Sutapa, Das Salil K, Mukherjee Shyamali
J Biomed Biotechnol. 2004;2004(4):195-202. doi: 10.1155/S1110724304401016.
Manganese superoxide dismutase (Mn-SOD), localized at the mitochondrial matrix, has the ability to protect cells against oxidative damage. It has been reported that low levels of Mn-SOD gene expression cause the development of certain kind of tumors. On the other hand, overexpression of Mn-SOD gene may play an important role in the development of cancer. In our study, we find that Mn-SOD activity was higher in nonaggressive (MCF-7) and aggressive (BT-549 and 11-9-14) breast cancer cell lines compared to that of nontumorigenic (MCF-12A and MCF-12F) mammary epithelial cell lines. We also observed an increased expression of Mn-SOD gene in cancerous cell lines. The elevated level of SOD activity in nonaggressive and aggressive breast epithelial cell lines was associated with some changes in nucleotide sequence.
锰超氧化物歧化酶（Mn-SOD）定位于线粒体基质，具有保护细胞免受氧化损伤的能力。据报道，低水平的Mn-SOD基因表达会导致某些类型肿瘤的发生。另一方面，Mn-SOD基因的过表达可能在癌症发展中起重要作用。在我们的研究中，我们发现与非致瘤性（MCF-12A和MCF-12F）乳腺上皮细胞系相比，非侵袭性（MCF-7）和侵袭性（BT-549和11-9-14）乳腺癌细胞系中的Mn-SOD活性更高。我们还观察到癌细胞系中Mn-SOD基因的表达增加。非侵袭性和侵袭性乳腺上皮细胞系中SOD活性的升高与核苷酸序列的一些变化有关。
