减数分裂重组中间体与错配修复蛋白
Meiotic recombination intermediates and mismatch repair proteins.
作者信息
Hoffmann E R, Borts R H
机构信息
Department of Genetics, University of Leicester, Leicester, UK.
出版信息
Cytogenet Genome Res. 2004;107(3-4):232-48. doi: 10.1159/000080601.
PMID:15467368
Abstract
Mismatch repair proteins are a highly diverse group of proteins that interact with numerous DNA structures during DNA repair and replication. Here we review data for the role of Msh4, Msh5, Mlh1, Mlh3 and Exo1 in crossing over. Based on the paradigm of interactions developed from studies of mismatch repair, we propose models for the mechanism of crossover implementation by Msh4/Msh5 and Mlh1/Mlh3.
摘要
错配修复蛋白是一类高度多样化的蛋白质，在DNA修复和复制过程中与众多DNA结构相互作用。在此，我们综述了Msh4、Msh5、Mlh1、Mlh3和Exo1在交叉过程中作用的数据。基于对错配修复研究中所建立的相互作用模式，我们提出了Msh4/Msh5和Mlh1/Mlh3实现交叉机制的模型。
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