Farbu Elisabeth, Rekand Tiina, Gilhus Nils Erik, Strøm Vegard, Opheim Arve, Stanghelle Johan Kvalvik, Aarli Johan A
Nevrologisk avdeling, Haukeland Universitetssykehus 5021 Bergen.
Tidsskr Nor Laegeforen. 2004 Sep 23;124(18):2357-8.
Postpolio syndrome is characterised by new muscular weakness, pain, and fatigue several decades after the acute polio, and affects approximately 1/4 of patients with previous paralytic polio.
A 47-year-old woman with a previous history of acute poliomyelitis developed progressive muscular weakness in her left arm and right leg with muscular pain and fatigue. Clinical examination, MRI, and electromyography gave no other explanation to her progressive muscular weakness and fatigue than postpolio syndrome. She was treated with 400 mg/kg immunoglobulin intravenously for five consecutive days.
At follow-up two and three months later, she had a considerable increase in isokinetic muscle strength in knee extension and flexion on the right side, and experienced less fatigue.
This case suggests that stabilisation of an autoimmune dysfunction may be a therapeutic option in postpolio syndrome.
小儿麻痹后遗症的特征是在急性脊髓灰质炎发作数十年后出现新的肌肉无力、疼痛和疲劳，约四分之一既往患过麻痹性脊髓灰质炎的患者会受其影响。
一名47岁女性，有急性脊髓灰质炎病史，出现左臂和右腿进行性肌肉无力，并伴有肌肉疼痛和疲劳。临床检查、磁共振成像（MRI）和肌电图检查结果表明，除小儿麻痹后遗症外，没有其他原因可以解释她进行性肌肉无力和疲劳的症状。她接受了连续五天、每天400毫克/千克的静脉注射免疫球蛋白治疗。
在随后两个月和三个月的随访中，她右侧膝关节屈伸的等速肌力显著增强，疲劳感减轻。
该病例表明，稳定自身免疫功能障碍可能是小儿麻痹后遗症的一种治疗选择。
