Shimokuri Taiki, Kaneko Tatsuo, Serizawa Takeshi, Akashi Mitsuru
Department of Nanostructured and Advanced Materials, Graduate School of Science and Engineering, Kagoshima University, 1-21-40, Korimoto, Kagoshima 890-0065, Japan.
Macromol Biosci. 2004 Apr 19;4(4):407-11. doi: 10.1002/mabi.200300073.
Poly(gamma-glutamic acid) (gamma-PGA) is a biosynthetic polymer, and the carboxyl groups are able to undergo a chemical modification. In this study, poly(alpha-propyl gamma-glutamate) (gamma-PGA propylate) was synthesized by the esterification of these carboxyl groups to yield a thermosensitive and biodegradable polymer. In aqueous solution, the gamma-PGA propylate can impart thermosensitivity by controlling the hydrophobic-hydrophilic balance of the gamma-PGA polymeric chains.
聚（γ-谷氨酸）（γ-PGA）是一种生物合成聚合物，其羧基能够进行化学修饰。在本研究中，通过这些羧基的酯化反应合成了聚（α-丙基γ-谷氨酸酯）（γ-PGA丙酯），以得到一种热敏性和可生物降解的聚合物。在水溶液中，γ-PGA丙酯可通过控制γ-PGA聚合物链的疏水-亲水平衡来赋予热敏性。
