丙基修饰的天然存在的多肽聚（γ-谷氨酸）衍生物的制备及其热敏性

Preparation and thermosensitivity of naturally occurring polypeptide poly(gamma-glutamic acid) derivatives modified by propyl groups.

作者信息

Shimokuri Taiki, Kaneko Tatsuo, Serizawa Takeshi, Akashi Mitsuru

机构信息

Department of Nanostructured and Advanced Materials, Graduate School of Science and Engineering, Kagoshima University, 1-21-40, Korimoto, Kagoshima 890-0065, Japan.

出版信息

Macromol Biosci. 2004 Apr 19;4(4):407-11. doi: 10.1002/mabi.200300073.

DOI:10.1002/mabi.200300073

PMID:15468231

Abstract

Poly(gamma-glutamic acid) (gamma-PGA) is a biosynthetic polymer, and the carboxyl groups are able to undergo a chemical modification. In this study, poly(alpha-propyl gamma-glutamate) (gamma-PGA propylate) was synthesized by the esterification of these carboxyl groups to yield a thermosensitive and biodegradable polymer. In aqueous solution, the gamma-PGA propylate can impart thermosensitivity by controlling the hydrophobic-hydrophilic balance of the gamma-PGA polymeric chains.

摘要

聚（γ-谷氨酸）（γ-PGA）是一种生物合成聚合物，其羧基能够进行化学修饰。在本研究中，通过这些羧基的酯化反应合成了聚（α-丙基γ-谷氨酸酯）（γ-PGA丙酯），以得到一种热敏性和可生物降解的聚合物。在水溶液中，γ-PGA丙酯可通过控制γ-PGA聚合物链的疏水-亲水平衡来赋予热敏性。