Sung Moon-Hee, Park Chung, Kim Chul-Joong, Poo Haryoung, Soda Kenji, Ashiuchi Makoto
Department of Bio & Nanochemistry, Kookmin University, 861-1 Chongnung-dong, Songbuk-gu, Seoul 136-702, Korea.
Chem Rec. 2005;5(6):352-66. doi: 10.1002/tcr.20061.
Poly-gamma-glutamic acid (gamma-PGA) is a very promising biodegradable polymer that is produced by Bacillus subtilis. Gamma-PGA is water-soluble, anionic, biodegradable, and edible. This paper reviews the production of a strain of gamma-PGA and recent developments with respect to applications in terms of Ca absorption, moisturizing properties, gamma-PGA conjugation, super absorbent polymer, and so on. Our recent research shows that gamma-PGA can be used as an immune-stimulating and anti-tumor agent, especially at high molecular weight.
聚γ-谷氨酸(γ-PGA)是一种非常有前景的可生物降解聚合物,由枯草芽孢杆菌产生。γ-PGA具有水溶性、阴离子性、可生物降解性且可食用。本文综述了γ-PGA菌株的生产以及在钙吸收、保湿性能、γ-PGA偶联、高吸水性聚合物等应用方面的最新进展。我们最近的研究表明,γ-PGA可作为免疫刺激剂和抗肿瘤剂,尤其是高分子量的γ-PGA。