Hood S, Evans J, Bond J, Wilkins E, Denning D
Department of Infectious Diseases and Tropical Medicine, North Manchester General Hospital, Manchester, England.
AIDS Patient Care STDS. 1998 Aug;12(8):625-7. doi: 10.1089/apc.1998.12.625.
Oropharyngeal candidiasis (OPC) is the most frequent opportunistic infection associated with HIV infection. Therapies such as topical clotrimazole and nystatin, as well as oral azoles, which had previously been effective prior to the advent of HIV, are increasingly only partially effective in OPC in HIV infection. The effectiveness of oral amphotericin B suspension for OPC is described in 17 HIV-infected patients whose response to other therapies had been unsatisfactory. Three patients yielded isolates of Candida albicans with a minimum inhibitory concentration (MIC) to fluconazole of >/=16 microg/mL. Eleven patients received amphotericin B suspension monotherapy. Of the 17 patients, the symptoms of six resolved entirely, seven patients partially responded, and four failed therapy. These data suggest that amphotericin B suspension may be a useful additional therapy for OPC in HIV-infected patients.
口腔念珠菌病（OPC）是与HIV感染相关的最常见机会性感染。在HIV出现之前曾有效的局部克霉唑和制霉菌素等疗法，以及口服唑类药物，在HIV感染的OPC中越来越仅部分有效。17例对其他疗法反应不佳的HIV感染患者中描述了口服两性霉素B混悬液治疗OPC的有效性。3例患者分离出对氟康唑的最低抑菌浓度（MIC）≥16μg/mL的白色念珠菌。11例患者接受了两性霉素B混悬液单药治疗。17例患者中，6例症状完全缓解，7例部分缓解，4例治疗失败。这些数据表明，两性霉素B混悬液可能是HIV感染患者OPC的一种有用的辅助治疗方法。
