Hauser Oliver, Prieschl-Grassauer Eva, Salmons Brian
Research Institute for Virology and Biomedicine, University of Veterinary Medicine, Veterinaerplatz 1, A-1210 Vienna, Austria.
Curr Opin Mol Ther. 2004 Aug;6(4):412-20.
The ability to implant genetically modified cells in immuno-isolating materials has much potential for therapeutic use. This review presents the different types of polymer that can be used for encapsulation of cells and the recent use of genetically modified, encapsulated and thus immunoprotected cells for the treatment of diseases in animal models and clinical trials. Some of the challenges faced by these technologies and potential solutions are also discussed.
将基因修饰细胞植入免疫隔离材料中的能力在治疗应用方面具有很大潜力。本文综述了可用于细胞封装的不同类型聚合物，以及基因修饰、封装并因此获得免疫保护的细胞在动物模型疾病治疗和临床试验中的最新应用。还讨论了这些技术面临的一些挑战及潜在解决方案。
