Gao Jianmin, Watanabe Soichiro, Kool Eric T
Department of Chemistry, Stanford University, Stanford, CA 94305-5080, USA.
J Am Chem Soc. 2004 Oct 13;126(40):12748-9. doi: 10.1021/ja046910o.
We report the discovery of a new class of light-sensing molecules. These light sensors are composed of fluorophore oligomers assembled on a DNA backbone. A combinatorial library of tetrafluorophores consisting of over 14 000 compounds was synthesized and screened for rapid responses toward light exposure. Among the most light-sensitive molecules, at least three tetramers were found to respond to light exposure with apparent color changes, rather than simple photobleaching.
我们报告了一类新型光感测分子的发现。这些光传感器由组装在DNA主链上的荧光团低聚物组成。合成了一个由超过14000种化合物组成的四荧光团组合文库，并筛选其对光照的快速响应。在最敏感的分子中，发现至少有三种四聚体对光照有明显的颜色变化反应，而不是简单的光漂白。
