通过Sonogashira偶联高效合成荧光炔基C-核苷用于制备基于DNA的多荧光团。
Efficient synthesis of fluorescent alkynyl C-nucleosides via Sonogashira coupling for the preparation of DNA-based polyfluorophores.
作者信息
Kölmel Dominik K, Barandun Luzi J, Kool Eric T
机构信息
Department of Chemistry, Stanford University, Stanford, California 94305, USA.
出版信息
Org Biomol Chem. 2016 Jul 6;14(27):6407-12. doi: 10.1039/c6ob01199c.
Abstract
A facile and general procedure for the preparation of alkynyl C-nucleosides with varied fluorophores is presented. Sonogashira coupling was used as a key reaction to conjugate the dyes to an easily accessible ethynyl functionalized deoxyribose derivative. The new C-nucleosides were used for the preparation of DNA-based polyfluorophores.
摘要
本文介绍了一种简便通用的方法来制备带有各种荧光团的炔基碳核苷。Sonogashira偶联反应被用作关键反应，将染料与易于获得的乙炔基官能化脱氧核糖衍生物共轭。这些新型碳核苷用于制备基于DNA的多荧光团。
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