Bacqué Eric, El Qacemi Myriem, Zard Samir Z
AVENTIS Pharma, 94 400 Vitry sur Seine, France.
Org Lett. 2004 Oct 14;6(21):3671-4. doi: 10.1021/ol0489649.
[reaction: see text] Compounds containing a pyridine nucleus fused to a saturated nitrogen-containing ring, including 7-azaoxindoles, 7-azaindolines, tetrahydro[1,8]naphthyridines, and tetrahydro-5H-pyrido[2,3-b]azepin-8-ones, were prepared in good yield starting from various 2,6-dichloropyridines. The method hinges on a free-radical xanthate-mediated cyclization or intermolecular addition/cyclization sequence for the construction of the new fused rings.
[反应：见正文] 从各种2,6 - 二氯吡啶出发，以良好的产率制备了含有与饱和含氮环稠合的吡啶核的化合物，包括7 - 氮杂氧化吲哚、7 - 氮杂二氢吲哚、四氢[1,8]萘啶和四氢 - 5H - 吡啶并[2,3 - b]氮杂䓬 - 8 - 酮。该方法基于自由基黄原酸酯介导的环化或分子间加成/环化序列来构建新的稠合环。
