通过钴催化的[2 + 2 + 2]环化反应合成5,6,7,8-四氢-1,6-萘啶及相关杂环化合物。
Synthesis of 5,6,7,8-tetrahydro-1,6-naphthyridines and related heterocycles by cobalt-catalyzed [2 + 2 + 2] cyclizations.
作者信息
Zhou Ya, Porco John A, Snyder John K
机构信息
Department of Chemistry and the Center for Methodology and Library Development, Boston University, Boston, Massachusetts 02215, USA.
出版信息
Org Lett. 2007 Feb 1;9(3):393-6. doi: 10.1021/ol0625280.
PMID:17249770
Abstract
[reaction: see text] Microwave-promoted, cobalt-catalyzed intramolecular [2 + 2 + 2] cyclizations of dialkynylnitriles successfully gave 5,6,7,8-tetrahydro-1,6-naphthyridines. The efficient synthesis of these relatively simple, yet rarely addressed heterocycles enabled the preparation of a collection of these compounds.
摘要
[反应：见正文] 微波促进、钴催化的二炔腈分子内[2 + 2 + 2]环化反应成功得到了5,6,7,8-四氢-1,6-萘啶。这些相对简单但很少被研究的杂环化合物的高效合成使得能够制备一系列此类化合物。
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