使用普林斯-频哪醇反应立体控制构建12-氧杂三环[6.3.1.0(2,7)]十二烷的任一立体异构体。
Stereocontrolled construction of either stereoisomer of 12-oxatricyclo[6.3.1.0(2,7)]dodecanes using Prins-pinacol reactions.
作者信息
Overman Larry E, Velthuisen Emile J
机构信息
Department of Chemistry, 516 Rowland Hall, University of California, Irvine, California 92697-2025, USA.
出版信息
Org Lett. 2004 Oct 14;6(21):3853-6. doi: 10.1021/ol0482745.
PMID:15469366
Abstract
[reaction: see text] 12-Oxatricyclo[6.3.1.0(2,7)]dodecanes can be efficiently synthesized in a stereoselective manner by Prins-pinacol reactions. By biasing the transition state of the Prins cyclization, it is possible to access either stereoisomer of this oxatricyclic ring system.
摘要
[反应：见正文] 12-氧杂三环[6.3.1.0(2,7)]十二烷可通过普林斯-频哪醇反应以立体选择性方式高效合成。通过使普林斯环化的过渡态产生偏向，有可能获得该氧杂三环体系的任意一种立体异构体。
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