Baldacci Patricia, Ménard Robert
Unité de Biologie et Génétique du Paludisme, Institut Pasteur, Paris, France.
Mol Microbiol. 2004 Oct;54(2):298-306. doi: 10.1111/j.1365-2958.2004.04275.x.
Malaria infection is initiated when Plasmodium sporozoites are injected into a host during the bite of an infected mosquito. In the mammal, the sporozoite must rapidly reach an intravacuolar niche within a hepatocyte, where it will generate the parasite stage that invades red blood cells and causes the symptoms of the disease. Herein, we describe our understanding of the way in which sporozoites travel from the site of the mosquito bite to the liver, arrest in the liver, cross the sinusoidal barrier and eventually gain access to hepatocytes. We also highlight some of the recent advances in our understanding of these processes at the molecular level.
当受感染蚊子叮咬时，疟原虫子孢子被注入宿主体内，疟疾感染由此开始。在哺乳动物体内，子孢子必须迅速到达肝细胞内的液泡内龛位，在那里它会产生侵入红细胞并引发疾病症状的寄生虫阶段。在此，我们描述了我们对子孢子从蚊子叮咬部位传播到肝脏、在肝脏中滞留、穿过窦状屏障并最终进入肝细胞的方式的理解。我们还强调了在分子水平上对这些过程的理解方面的一些最新进展。
