Amino Rogerio, Thiberge Sabine, Shorte Spencer, Frischknecht Friedrich, Ménard Robert
Unité de biologie et génétique du paludisme, Institut Pasteur, 25-28, rue du Docteur-Roux, 75724 Paris cedex 15, France.
C R Biol. 2006 Nov;329(11):858-62. doi: 10.1016/j.crvi.2006.04.003. Epub 2006 Aug 17.
Malaria, the disease caused by Plasmodium, kills more than 1 million people annually. Little is known of the pre-erythrocytic phase of the parasite life cycle, i.e., after the sporozoite stage is inoculated in the dermis by a mosquito and before the erythrocyte-infecting stage is released from hepatocytes. We present here a quantitative, real-time analysis of the fate of parasites transmitted in a rodent system. We describe previously unrecognized steps in the parasite's journey to the liver of the host, which are likely to play an important role in the host immune response.
疟疾是由疟原虫引起的疾病，每年导致超过100万人死亡。人们对寄生虫生命周期的红细胞前期知之甚少，即疟原虫子孢子阶段经蚊子接种到真皮后，到感染红细胞阶段从肝细胞释放之前的这段时间。我们在此展示了对在啮齿动物系统中传播的寄生虫命运的定量实时分析。我们描述了寄生虫进入宿主肝脏过程中以前未被认识到的步骤，这些步骤可能在宿主免疫反应中发挥重要作用。
