Hartemink Koen J, Wisselink Willem, Rauwerda Jan A, Girbes Armand R J, Polderman Kees H
Department of Intensive Care and Surgery, VU University Medical Center, Amsterdam, The Netherlands.
Crit Care. 2004 Oct;8(5):R343-6. doi: 10.1186/cc2928. Epub 2004 Aug 18.
Therapeutic hypothermia can provide neuroprotection in various situations where global or focal neurological injury has occurred. Hypothermia has been shown to be effective in a large number of animal experiments. In clinical trials, hypothermia has been used in patients with postanoxic injury following cardiopulmonary resuscitation, in traumatic brain injury with high intracranial pressure, in the perioperative setting during various surgical procedures and for various other indications. There is thus evidence that hypothermia can be effective in various situations of neurological injury, although a number of questions remain unanswered. We describe three patients with unusual causes of neurological injury, whose clinical situation was in fundamental aspects analogous to conditions where hypothermia has been shown to be effective.
治疗性低温可在发生全脑或局灶性神经损伤的各种情况下提供神经保护作用。低温已在大量动物实验中被证明是有效的。在临床试验中，低温已被用于心肺复苏后缺氧性脑损伤患者、颅内压高的创伤性脑损伤患者、各种外科手术围手术期以及其他各种适应症。因此，有证据表明低温在各种神经损伤情况下可能有效，尽管仍有许多问题未得到解答。我们描述了三名神经损伤病因不寻常的患者，他们的临床情况在基本方面与已证明低温有效的情况相似。
