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Role of iron in anaemic critically ill patients: it's time to investigate!铁在贫血危重症患者中的作用：是时候进行研究了！
Crit Care. 2004 Oct;8(5):306-7. doi: 10.1186/cc2884. Epub 2004 Jun 3.
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Efficacy of recombinant human erythropoietin in critically ill patients admitted to a long-term acute care facility: a randomized, double-blind, placebo-controlled trial.重组人促红细胞生成素对入住长期急性护理机构的重症患者的疗效：一项随机、双盲、安慰剂对照试验。
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Iron deficiency diagnosed using hepcidin on critical care discharge is an independent risk factor for death and poor quality of life at one year: an observational prospective study on 1161 patients.铁缺乏症使用铁调素在重症监护病房出院时诊断是死亡和一年时生活质量差的独立危险因素：对 1161 例患者的观察性前瞻性研究。
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Serum iron levels are an independent predictor of in-hospital mortality of critically ill patients: a retrospective, single-institution study.血清铁水平是危重症患者院内死亡率的独立预测因素：一项回顾性单机构研究。
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Recommendations on RBC Transfusion in Infants and Children With Acquired and Congenital Heart Disease From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative.儿科危重病输血和贫血专业知识倡议：关于获得性和先天性心脏病婴儿和儿童的 RBC 输血建议。
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本文引用的文献

1
Bench-to-bedside review: iron metabolism in critically ill patients.从实验台到病床的综述：危重症患者的铁代谢
Crit Care. 2004 Oct;8(5):356-62. doi: 10.1186/cc2862. Epub 2004 May 13.
2
Alterations of red blood cell shape and sialic acid membrane content in septic patients.脓毒症患者红细胞形态及唾液酸膜含量的改变
Crit Care Med. 2003 Aug;31(8):2156-62. doi: 10.1097/01.CCM.0000079608.00875.14.
3
Red blood cell rheology in sepsis.脓毒症中的红细胞流变学
Intensive Care Med. 2003 Jul;29(7):1052-61. doi: 10.1007/s00134-003-1783-2. Epub 2003 Jun 12.
4
Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation.铁调素，铁代谢的关键调节因子及炎症性贫血的介质。
Blood. 2003 Aug 1;102(3):783-8. doi: 10.1182/blood-2003-03-0672. Epub 2003 Mar 27.
5
Time course of hemoglobin concentrations in nonbleeding intensive care unit patients.非出血性重症监护病房患者血红蛋白浓度的时间进程
Crit Care Med. 2003 Feb;31(2):406-10. doi: 10.1097/01.CCM.0000048623.00778.3F.
6
Cytokine-mediated regulation of iron transport in human monocytic cells.细胞因子介导的人类单核细胞中铁转运的调节
Blood. 2003 May 15;101(10):4148-54. doi: 10.1182/blood-2002-08-2459. Epub 2003 Jan 9.
7
Efficacy of recombinant human erythropoietin in critically ill patients: a randomized controlled trial.重组人促红细胞生成素对危重症患者的疗效：一项随机对照试验。
JAMA. 2002 Dec 11;288(22):2827-35. doi: 10.1001/jama.288.22.2827.
8
Anemia and blood transfusion in critically ill patients.危重症患者的贫血与输血
JAMA. 2002 Sep 25;288(12):1499-507. doi: 10.1001/jama.288.12.1499.
9
Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice.血红素加氧酶-1介导白细胞介素-10在小鼠体内的抗炎作用。
Nat Med. 2002 Mar;8(3):240-6. doi: 10.1038/nm0302-240.
10
Pure red-cell aplasia and antierythropoietin antibodies in patients treated with recombinant erythropoietin.接受重组促红细胞生成素治疗的患者中的纯红细胞再生障碍和抗促红细胞生成素抗体
N Engl J Med. 2002 Feb 14;346(7):469-75. doi: 10.1056/NEJMoa011931.

铁在贫血危重症患者中的作用：是时候进行研究了！

Role of iron in anaemic critically ill patients: it's time to investigate!

作者信息

Piagnerelli Michael, Vincent Jean-Louis

机构信息

Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium.

出版信息

Crit Care. 2004 Oct;8(5):306-7. doi: 10.1186/cc2884. Epub 2004 Jun 3.

DOI:10.1186/cc2884
PMID:15469585
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1065009/
Abstract

Anaemia is a common problem in critically ill patients admitted to intensive care units. Many factors can be involved in its development, including rapid alterations of iron metabolism. Maintenance of iron homeostasis is a prerequisite for many essential biological processes and a central element for the development of erythroid precursors and mature red blood cells. With the inflammatory process, iron distribution is disturbed, with decreased serum iron levels and increased iron stores. Little information is available on the precise role of alterations of iron metabolism in the development of iron anaemia in critically ill patients.

摘要

贫血是重症监护病房中危重症患者的常见问题。其发生可能涉及多种因素，包括铁代谢的快速改变。维持铁稳态是许多重要生物学过程的前提条件，也是红系前体细胞和成熟红细胞发育的核心要素。随着炎症过程的发生，铁的分布受到干扰，血清铁水平降低，铁储存增加。关于铁代谢改变在危重症患者缺铁性贫血发生中的确切作用，目前所知甚少。