铁在贫血危重症患者中的作用：是时候进行研究了！
Role of iron in anaemic critically ill patients: it's time to investigate!
作者信息
Piagnerelli Michael, Vincent Jean-Louis
机构信息
Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium.
出版信息
Crit Care. 2004 Oct;8(5):306-7. doi: 10.1186/cc2884. Epub 2004 Jun 3.
Abstract
Anaemia is a common problem in critically ill patients admitted to intensive care units. Many factors can be involved in its development, including rapid alterations of iron metabolism. Maintenance of iron homeostasis is a prerequisite for many essential biological processes and a central element for the development of erythroid precursors and mature red blood cells. With the inflammatory process, iron distribution is disturbed, with decreased serum iron levels and increased iron stores. Little information is available on the precise role of alterations of iron metabolism in the development of iron anaemia in critically ill patients.
摘要
贫血是重症监护病房中危重症患者的常见问题。其发生可能涉及多种因素，包括铁代谢的快速改变。维持铁稳态是许多重要生物学过程的前提条件，也是红系前体细胞和成熟红细胞发育的核心要素。随着炎症过程的发生，铁的分布受到干扰，血清铁水平降低，铁储存增加。关于铁代谢改变在危重症患者缺铁性贫血发生中的确切作用，目前所知甚少。
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