Kestin I G, Madden A P, Mulvein J T, Goodman N W
University of Bristol Department of Anaesthesia, Southmead Hospital, Westbury-on-Trym.
Br J Anaesth. 1992 Mar;68(3):244-7. doi: 10.1093/bja/68.3.244.
Twenty mothers who had requested regional analgesia during labour had a 32-gauge catheter inserted into the lumbar subarachnoid space. The mean time to place the catheters was 116 s (range 55-270 s) and there were no technical difficulties. Incremental diamorphine was given, up to a maximum initial dose of 0.5 mg. Analgesia was excellent in 11 mothers, good in seven and unsatisfactory in two. The duration of initial analgesia from diamorphine was 101 min (range 30-170 min). Eight mothers were able to move about during the first stage, with effective analgesia. Side effects were common: 15 mothers had pruritus, 15 had nausea or vomiting, and eight had mild sedation. No mother had a ventilatory frequency of less than 12 b.p.m. in the 12 h after the last dose of intrathecal diamorphine. Intrathecal 0.5% bupivacaine was given to 16 mothers in the first stage because the analgesia after a top-up with diamorphine became insufficient later in the labour. Fifteen mothers were pain free after bupivacaine; there was one failure. The initial effective dose of bupivacaine was between 0.25 ml and 2 ml. The maximum height of the block after bupivacaine was T9, and there was no hypotension. Nine mothers were given hyperbaric 0.5% bupivacaine 1-2 ml during the second stage; all were pain free for the procedure. The maximum force needed to withdraw the catheters was 700 g; and all catheters were removed intact. There were no post-spinal headaches.
20名在分娩期间要求进行区域镇痛的产妇在腰蛛网膜下腔插入了32G导管。放置导管的平均时间为116秒(范围55 - 270秒),且无技术困难。给予递增剂量的二氢吗啡,最大初始剂量为0.5毫克。11名产妇镇痛效果极佳,7名良好,2名不满意。二氢吗啡初始镇痛持续时间为101分钟(范围30 - 170分钟)。8名产妇在第一产程能够活动,且镇痛效果良好。副作用常见:15名产妇有瘙痒,15名有恶心或呕吐,8名有轻度镇静。在最后一剂鞘内注射二氢吗啡后的12小时内,没有产妇的呼吸频率低于12次/分钟。16名产妇在第一产程给予鞘内0.5%布比卡因,因为在分娩后期追加二氢吗啡后镇痛效果不足。15名产妇在使用布比卡因后无痛;有1例失败。布比卡因的初始有效剂量在0.25毫升至2毫升之间。布比卡因麻醉平面最高达T9,且无低血压。9名产妇在第二产程给予1 - 2毫升高压0.5%布比卡因;所有产妇在此过程中均无痛。拔出导管所需的最大力量为700克;所有导管均完整拔出。无脊麻后头痛发生。