Naguib M, Sari-Kouzel A, Seraj M, el-Gammal M, Gomma M
Department of Critical Care Medicine, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al-Ain.
Br J Anaesth. 1992 Mar;68(3):308-10. doi: 10.1093/bja/68.3.308.
The relative potencies of propofol and thiopentone were assessed using different indicators of induction of anaesthesia: abolition of the response to verbal commands and eyelash stimulation. Log-probit dose-response curves for these end-points were determined 30, 60 and 90 s after induction in 96 unpremedicated ASA group I patients. For propofol, ED50 values for abolition of the response to verbal commands and eyelash stimulation at different time intervals were in the ranges 1.16-1.42 and 1.23-1.72 mg kg-1, respectively; corresponding ED95 values were 2.18-2.67 and 2.42-3.27 mg kg-1, respectively. For thiopentone, the calculated ED50 values for verbal commands and eyelash stimulation at the same time intervals were 1.81-2.23 and 3.55-3.40 mg kg-1; corresponding ED95 values were 5.11-6.29 and 6.41-6.70 mg kg-1, respectively. The potency ratio of propofol to thiopentone observed in this study varied from 1:1.27 to 1:2.88. It is concluded that a dose-response curve reflecting one end-point of anaesthesia cannot be used to define another end-point of anaesthesia.
使用不同的麻醉诱导指标（对言语指令和睫毛刺激反应的消失）评估丙泊酚和硫喷妥钠的相对效价。在96例未使用术前药的ASA I级患者诱导后30、60和90秒测定这些终点的对数概率剂量-反应曲线。对于丙泊酚，不同时间间隔下对言语指令反应消失和睫毛刺激反应消失的ED50值分别在1.16 - 1.42和1.23 - 1.72mg·kg-1范围内；相应的ED95值分别为2.18 - 2.67和2.42 - 3.27mg·kg-1。对于硫喷妥钠，相同时间间隔下对言语指令和睫毛刺激反应的计算ED50值分别为1.81 - 2.23和3.55 - 3.40mg·kg-1；相应的ED95值分别为5.11 - 6.29和6.41 - 6.70mg·kg-1。本研究中观察到的丙泊酚与硫喷妥钠的效价比在1:1.27至1:2.88之间。得出的结论是，反映麻醉一个终点的剂量-反应曲线不能用于定义麻醉的另一个终点。
