Raaymakers B W, Raaijmakers A J E, Kotte A N T J, Jette D, Lagendijk J J W
Department of Radiotherapy, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.
Phys Med Biol. 2004 Sep 7;49(17):4109-18. doi: 10.1088/0031-9155/49/17/019.
Integrating magnetic resonance imaging (MRI) functionality with a radiotherapy accelerator can facilitate on-line, soft-tissue based, position verification. A technical feasibility study, in collaboration with Elekta Oncology Systems and Philips Medical Systems, led to the preliminary design specifications of a MRI accelerator. Basically the design is a 6 MV accelerator rotating around a 1.5 T MRI system. Several technical issues and the clinical rational are currently under investigation. The aim of this paper is to determine the impact of the transverse 1.5 T magnetic field on the dose deposition. Monte Carlo simulations were used to calculate the dose deposition kernel in the presence of 1.5 T. This kernel in turn was used to determine the dose deposition for larger fields. Also simulations and measurements were done in the presence of 1.1 T. The pencil beam dose deposition is asymmetric. For larger fields the asymmetry persists but decreases. For the latter the distance to dose maximum is reduced by approximately 5 mm, the penumbra is increased by approximately 1 mm, and the 50% isodose line is shifted approximately 1 mm. The dose deposition in the presence of 1.5 T is affected, but the effect can be taken into account in a conventional treatment planning procedure. The impact of the altered dose deposition for clinical IMRT treatments is the topic of further research.
将磁共振成像(MRI)功能与放射治疗加速器相结合,有助于进行基于软组织的在线位置验证。与医科达肿瘤系统公司和飞利浦医疗系统公司合作开展的一项技术可行性研究,得出了MRI加速器的初步设计规格。该设计基本上是一台围绕1.5T MRI系统旋转的6MV加速器。目前正在研究几个技术问题和临床合理性。本文的目的是确定1.5T横向磁场对剂量沉积的影响。使用蒙特卡罗模拟来计算在1.5T磁场存在下的剂量沉积核。该核继而用于确定更大射野的剂量沉积。同时也在1.1T磁场存在的情况下进行了模拟和测量。笔形束剂量沉积是不对称的。对于更大射野,这种不对称性仍然存在但有所减小。对于后者,到剂量最大值的距离减少了约5mm,半值层增加了约1mm,50%等剂量线偏移了约1mm。1.5T磁场存在时的剂量沉积会受到影响,但这种影响可以在传统治疗计划程序中加以考虑。临床调强放射治疗中剂量沉积改变的影响是进一步研究的主题。