Browning William D, Chan Daniel C N, Frazier Kevin B, Callan Richard S, Blalock John S
Clinical Research, Department of Oral Rehabilitation, School of Dentistry, Medical College of Georgia, Augusta, Georgia, USA.
Quintessence Int. 2004 Oct;35(9):693-8.
Transient sensitivity during bleaching is generally reported to affect 67% of patients. While most people tolerate this sensitivity, some find it impossible to continue treatment. The purpose of this study was to determine the safety and efficacy of an experimental, low-sensitivity bleaching agent.
Twenty-two participants bleached for a minimum of 6 hours per night over a 2-week period. The bleaching agent used, Experimental Product E, is a 10% carbamide peroxide gel containing potassium nitrate and sodium fluoride. Evaluations were performed at baseline and 1,2,13, and 26 weeks. Color change was measured using a value-ordered Vita classic shade guide and a colorimeter. Sensitivity of the teeth, gingiva, tongue, and/or throat was measured daily using a patient log.
The median color change after 2 weeks was eight tabs. Approximately 36% reported sensitivity during the active whitening phase of the study. As a group, participants reported sensitivity during 13.7% of the total days spent whitening.
Experimental Product E was shown to be safe. Participants experienced minor sensitivity during the active bleaching phase only. Experimental Product E was shown to be an effective bleaching agent for the subjects tested in this study.
据报道，漂白过程中的短暂敏感现象通常会影响67%的患者。虽然大多数人能耐受这种敏感，但有些人发现无法继续治疗。本研究的目的是确定一种实验性低敏感漂白剂的安全性和有效性。
22名参与者在两周内每晚至少漂白6小时。所使用的漂白剂，即实验产品E，是一种含硝酸钾和氟化钠的10%过氧化脲凝胶。在基线以及第1、2、13和26周进行评估。使用色序排列的Vita经典比色板和色度计测量颜色变化。每天使用患者日志记录牙齿、牙龈、舌头和/或喉咙的敏感度。
两周后的颜色变化中位数为8个色阶。在研究的积极美白阶段，约36%的人报告有敏感现象。作为一个群体，参与者在美白总天数的13.7%期间报告有敏感现象。
实验产品E被证明是安全的。参与者仅在积极漂白阶段经历了轻微敏感。实验产品E被证明是本研究中受试对象的一种有效漂白剂。
